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Trolamine salicylate is an organic compound which is the salt formed between triethanolamine and salicylic acid.
It is used as an ingredient in sunscreens, analgesic creams, and cosmetics. The salicylic acid portion contributes to both the sun protection effect (by absorbing UVB radiation) and to the analgesic effect. The triethanolamine neutralizes the acidity of the salicylic acid. One benefit of this topical analgesic is that it has no odor, in contrast to other topical analgesics such as menthol.
The US Food and Drug Administration has not reviewed any of the over-the-counter products listed in the Daily Med database that contain trolamine salicylate. Also, the producers of trolamine salicylate products have not provided evidence to the FDA in support of claims that this chemical is directly absorbed through the skin into underlying tissue.
Triethanolamine, often abbreviated as TEA, is a viscous organic compound that is both a tertiary amine and a triol. A triol is a molecule with three alcohol groups. Like other amines, triethanolamine is a weak base. Triethanolamine can also be abbreviated as TEOA, which can help to distinguish it from triethylamine. Approximately 150000 metric tons were produced in 1999. It is a colourless compound although samples may appear yellow because of impurities.
Production
Triethanolamine is produced from the reaction of ethylene oxide with aqueous ammonia, also produced are ethanolamine and diethanolamine. The ratio of the products can be controlled by changing the stoichiometry of the reactants
Applications
Triethanolamine is used primarily as an emulsifier and surfactant. It is a common ingredient in formulations used for both industrial and consumer products. The triethanolamine neutralizes fatty acids, adjusts and buffers the pH, and solubilises oils and other ingredients that are not completely soluble in water. Some common products in which triethanolamine is found are liquid laundry detergents, dishwashing liquids, general cleaners, hand cleaners, polishes, metalworking fluids, paints, shaving cream and printing inks.
Cement production
Triethanolamine is also used as organic additive (0.1 wt. %) in the grinding of cement clinker. It facilitates the grinding process by preventing agglomeration and coating of the powder at the surface of balls and mill wall.
Cosmetics and medicine
Various ear diseases and infections are treated with eardrops containing triethanolamine polypeptide oleate-condensate, such as Cerumenex in the United States. In pharmaceutics, triethanolamine is the active ingredient of some ear drops used to treat impacted earwax. It also serves as a pH balancer in many different cosmetic products - ranging from cleansing creams and milks, skin lotions, eye gels, moisturizers, shampoos, shaving foams etc.
In the laboratory and in amateur photography
Another common use of TEA is as a complexing agent for aluminium ions in aqueous solutions. This reaction is often used to mask such ions before complexometric titrations with another chelating agent such as EDTA. TEA has also been used in photographic (silver halide) processing. It has been promoted as a useful alkali by amateur photographers.
In electroless plating
TEA is now commonly and very effectively used as a complexing agent in electroless plating.
Tumors
Reports indicated that TEA causes an increased incidence of tumor growth in the liver in female B6C3F1 mice, but not in male mice or in Fischer 344 rats. A 2004 study concluded "TEA may cause liver tumors in mice via a choline-depletion mode of action and that this effect is likely caused by the inhibition of choline uptake by cells."
Environmental toxicity
A 2009 study found that TEA has potential acute, sub-chronic and chronic toxicity properties in respect to aquatic species.
Regulation
TEA is listed under Schedule 3, part B of the Chemical Weapons Convention as it can be used in the manufacture of nitrogen mustards.
If you are allergic to tartrazine, talk with healthcare provider. Some products contain tartrazine.
If you have an allergy to any type of nuts or seeds, talk with healthcare provider. Some products contain nuts.
Check medicines with healthcare provider. This medicine may not mix well with other medicines.
Tell healthcare provider if you are pregnant or plan on getting pregnant.
Tell healthcare provider if you are breast-feeding.
What are some possible side effects of this medicine?
Skin irritation.
Reasons to call healthcare provider immediately
If you suspect an overdose, call your local poison control center or emergency department immediately.
Signs of a life-threatening reaction. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; fits; or swelling of face, lips, tongue, or throat.
Severe skin irritation.
Any rash.
No improvement in condition or feeling worse.
Trolamine salicylate is used to treat minor aches and pains of the muscles/joints (such as arthritis, backache, sprains). It belongs to a class of drugs known as salicylates.
How to use Myoflex topical
Follow all directions on the product package. If you are uncertain about any of the information, consult your doctor or pharmacist.
This medication is for use on the skin only. Do not get this medication in your eyes, inside your nose or mouth, or inside the vagina. If you do get the medication in those areas, flush with plenty of water.
Apply the medication to the affected area no more than 3 to 4 times a day. Rub in gently and thoroughly. After applying the medication, wash your hands unless you are using this medication to treat the hands.
Do not apply this medication on broken or irritated skin. Do not bandage or tightly wrap the affected area or apply heat to the area (such as using a heating pad). Doing so may increase the risk of side effects. Ask your pharmacist for more details.
Tell your doctor if your condition persists for more than 7 days, if it worsens, or if it keeps returning. If you think you may have a serious medical problem, get medical help right away.
If your doctor has directed you to use this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Stop using this medication and tell your doctor right away if any serious side effects occur, including: blistering/peeling/redness/irritation at the application site, nausea/vomiting, ringing in the ears.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
Before using trolamine salicylate, tell your doctor or pharmacist if you are allergic to it; or to aspirin or other salicylates (such as salsalate); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: asthma, growths in the nose (nasal polyps).
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
This drug is similar to aspirin. Children and teenagers should not use this drug if they have chickenpox, flu, or any undiagnosed illness or if they have recently received a vaccine. In these cases, this drug may increase the risk of Reye's syndrome, a rare but serious illness.
During the first 6 months of pregnancy, this medication should be used only when clearly needed. It is not recommended for use during the last 3 months of pregnancy due to possible harm to the unborn baby and problems with normal labor/delivery. Discuss the risks and benefits with your doctor.
It is unknown if this product passes into breast milk. Consult your doctor before breast-feeding.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
This medicine may be harmful if swallowed. If swallowing or overdose is suspected, contact a poison control center or emergency room immediately.
Notes
Keep all regular medical and laboratory appointments.
Missed Dose
If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
Storage
Store at room temperature away from heat, light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Information last revised September 2013. Copyright(c) 2013 First Databank, Inc.
