{"id":62116,"date":"2018-04-03T12:23:01","date_gmt":"2018-04-03T12:23:01","guid":{"rendered":"https:\/\/www.biphoo.com\/bipnews\/?p=62116"},"modified":"2018-04-03T12:23:01","modified_gmt":"2018-04-03T12:23:01","slug":"researchers-develop-injectable-bandage","status":"publish","type":"post","link":"https:\/\/www.biphoo.com\/bipnews\/health\/researchers-develop-injectable-bandage.html","title":{"rendered":"Researchers Develop Injectable Bandage"},"content":{"rendered":"

Researchers Develop Injectable Bandage<\/span><\/strong><\/h2>\n

A penetrating injury from shrapnel is a serious obstacle in overcoming battlefield wounds that can ultimately lead to death.Given the high mortality rates due to hemorrhaging, there is an unmet need to quickly self-administer materials that prevent fatality due to excessive blood loss.<\/span><\/p>\n

With a gelling agent commonly used in preparing pastries, researchers from the Inspired Nanomaterials and Tissue Engineering Laboratory have successfully fabricated an injectable bandage to stop bleeding and promote wound healing.<\/span><\/p>\n

In a recent article “Nanoengineered Injectable Hydrogels for Wound Healing Application” published in Acta Biomaterialia, Dr. Akhilesh K. Gaharwar, assistant professor in the Department of Biomedical Engineering at Texas A&M University, uses kappa-carrageenan and nanosilicates to form injectable hydrogels to promote hemostasis (the process to stop bleeding) and facilitate wound healing via a controlled release of therapeutics.<\/span><\/p>\n

“Injectable hydrogels are promising materials for achieving hemostasis in case of internal injuries and bleeding, as these biomaterials can be introduced into a wound site using minimally invasive approaches,” said Gaharwar. “An ideal injectable bandage should solidify after injection in the wound area and promote a natural clotting cascade. In addition, the injectable bandage should initiate wound healing response after achieving hemostasis.”<\/span><\/p>\n

The study uses a commonly used thickening agent known as kappa-carrageenan, obtained from seaweed, to design injectable hydrogels. Hydrogels are a 3-D water swollen polymer network, similar to Jell-O, simulating the structure of human tissues.<\/span><\/p>\n

When kappa-carrageenan is mixed with clay-based nanoparticles, injectable gelatin is obtained. The charged characteristics of clay-based nanoparticles provide hemostatic ability to the hydrogels. Specifically, plasma protein and platelets form blood adsorption on the gel surface and trigger a blood clotting cascade.<\/span><\/p>\n

“Interestingly, we also found that these injectable bandages can show a prolonged release of therapeutics that can be used to heal the wound” said Giriraj Lokhande, a graduate student in Gaharwar’s lab and first author of the paper. “The negative surface charge of nanoparticles enabled electrostatic interactions with therapeutics thus resulting in the slow release of therapeutics.”<\/span><\/p>\n

Source:-https:\/\/www.rdmag.com\/news\/2018\/04\/researchers-develop-injectable-bandage<\/span><\/p>\n

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