{"id":50388,"date":"2017-11-03T07:53:31","date_gmt":"2017-11-03T07:53:31","guid":{"rendered":"https:\/\/www.biphoo.com\/bipnews\/?p=50388"},"modified":"2017-11-03T07:53:31","modified_gmt":"2017-11-03T07:53:31","slug":"men-with-peyronies-disease-may-have-increased-risk-for-cancer","status":"publish","type":"post","link":"https:\/\/www.biphoo.com\/bipnews\/world-news\/men-with-peyronies-disease-may-have-increased-risk-for-cancer.html","title":{"rendered":"Men with Peyronie’s disease may have increased risk for cancer"},"content":{"rendered":"

Men with Peyronie’s disease may have increased risk for cancer<\/span><\/strong><\/span><\/h2>\n

Men with Peyronie’s disease may have increased risk for cancer:- Men with Peyronie\u2019s disease demonstrated an increased risk for cancer, according to a large retrospective cohort study presented at the American Society for Reproductive Cancer Scientific Congress and published in Fertility & Sterility.<\/span><\/p>\n

\u201cThis is the first study that both clinically and genetically links Peyronie\u2019s disease with other genetically linked diseases \u2014 in this case, cancer,\u201d Alexander W. Pastuszak, MD, PhD, assistant professor of urology at the Center for Reproductive Medicine at Baylor College of Medicine, told HemOnc Today. \u201cIt\u2019s an important set of findings because it demonstrates how certain benign conditions like Peyronie\u2019s disease can be associated with other more morbid conditions, such as cancer, and supports the need for continuous follow-up in men, as well as education of both patients and physicians about these types of associations.\u201d<\/span><\/p>\n

Peyronie\u2019s disease is the development of fibrous scar tissue inside the penis that causes curved and sometimes painful erections. It has been associated with erectile dysfunction.<\/span><\/p>\n

Researchers examined the risk for cancer among a sample of 48,423 men (mean age, 49.8 years) with Peyronie\u2019s disease compared with 1,117,428 men (mean age, 48.4 years) with erectile dysfunction and a control group of 484,230 men (mean age, 49.8 years).<\/span><\/p>\n

\u201cWe know that a genetic association exists between Peyronie\u2019s disease and two other fibrotic conditions \u2014 Dupuytren\u2019s disease and Ledderhose disease,\u201d Pastuszak said. \u201cWe also know that there are other chronic conditions that are genetically linked, so it was logical to examine whether Peyronie\u2019s disease was linked to cancer, particularly because this type of link would support the need for men with Peyronie\u2019s disease to be monitored for these conditions.\u201d<\/span><\/p>\n

Researchers analyzed data collected from MarketScan (Truven Health Analytics) claims from 2007 to 2014. They used a Cox regression model to compare incidence of cancer among the groups.<\/span><\/p>\n

Mean follow-up was 4.5 years in men with Peyronie\u2019s disease, 4.3 years in men with erectile dysfunction and 4.4 years in the control group.<\/span><\/p>\n

Men with erectile dysfunction had higher rates of obesity, hypertension, hyperlipidemia, smoking or diabetes than men with Peyronie\u2019s disease and age-matched controls.<\/span><\/p>\n

Compared with men with erectile dysfunction, men with Peyronie\u2019s disease had higher risks for stomach cancer (HR = 1.43; 95% CI, 1.02-2), melanoma (HR = 1.19; 95% CI, 1.02-1.38), testicular cancer (HR = 1.39; 95% CI, 1.05-1.84) and all cancers (HR = 1.1; 95% CI, 1.06-1.14).<\/span><\/p>\n

\u201cWe think there are genetic abnormalities that can predispose men to both Peyronie\u2019s disease, as well as certain cancers, and potentially other genetically linked conditions, as well,\u201d Pastuszak said. \u201cWe have some genetic data that support this association.<\/span><\/p>\n

\u201cWhat we know is that a link between Peyronie\u2019s disease and cancer exists, both clinically \u2014 when looking at a statistical association between Peyronie\u2019s disease and numerous cancers \u2014 as well as genetically, when comparing genetic sequence from men with Peyronie\u2019s disease and Dupuytren\u2019s disease with genes that can predispose to cancer,\u201d Pasutszak added. \u201cAs a result, men who are seen for Peyronie\u2019s disease and treated for this condition should be counseled and monitored after treatment for malignancy and other conditions.\u201d<\/span><\/p>\n

Researchers noted future studies should focus on confirming these associations and elucidating pathways between Peyronie\u2019s disease and cancer.<\/span><\/p>\n

\u201cWe need to more clearly define the relationship between Peyronie\u2019s disease and cancer by longitudinally following men with Peyronie\u2019s disease and\/or cancer to see if they develop reciprocal conditions,\u201d Pastuszak said. \u201cWe would also like to investigate the genetic alterations that we identified in men with Peyronie\u2019s disease and Dupuytren\u2019s disease to see whether they truly predispose to malignancies.\u201d\u2013 by Chuck Gormley<\/span><\/p>\n

Source:-\u00a0https:\/\/www.healio.com\/hematology-oncology\/gastrointestinal-cancer\/news\/in-the-journals\/%7B4a8cfb1d-c45d-494c-9a44-c55b40352d53%7D\/men-with-peyronies-disease-may-have-increased-risk-for-cancer<\/span><\/p>\n

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