{"id":12958,"date":"2016-10-03T12:33:22","date_gmt":"2016-10-03T12:33:22","guid":{"rendered":"http:\/\/www.biphoo.com\/bipnews\/?p=12958"},"modified":"2016-10-03T12:36:07","modified_gmt":"2016-10-03T12:36:07","slug":"yoshinori-ohsumi-of-japan-wins-nobel-prize-in-medicine","status":"publish","type":"post","link":"https:\/\/www.biphoo.com\/bipnews\/world-news\/yoshinori-ohsumi-of-japan-wins-nobel-prize-in-medicine.html","title":{"rendered":"Yoshinori Ohsumi of Japan Wins Nobel Prize in Medicine"},"content":{"rendered":"

Yoshinori Ohsumi of Japan Wins Nobel Prize in Medicine<\/span><\/strong><\/span><\/h2>\n

Yoshinori Ohsumi of Japan Wins Nobel Prize in Medicine<\/strong> : Yoshinori Ohsumi, a Japanese cell biologist, was awarded the Nobel Prize in Physiology or Medicine on Monday for his discoveries on how cells recycle their content, a process known as autophagy.<\/span><\/p>\n

Autophagy, derived from Greek, means \u201cself-eating.\u201d<\/span><\/p>\n

\u201cThis concept emerged during the 1960s, when researchers first observed that the cell could destroy its own contents by enclosing it in membranes, forming sacklike vesicles that were transported to a recycling compartment, called the lysosome, for degradation,\u201d the Nobel Assembly at Karolinska Institutet in Stockholm said in announcing the prize.<\/span><\/p>\n

In a series of experiments in the early 1990s, Dr. Ohsumi used baker\u2019s yeast to identify genes essential for autophagy, and he went on to examine the underlying mechanisms of the process.<\/span><\/p>\n

\u201cOhsumi\u2019s discoveries led to a new paradigm in our understanding of how the cell recycles its content,\u201d the Nobel Assembly said. \u201cHis discoveries opened the path to understanding the fundamental importance of autophagy in many physiological processes, such as in the adaptation to starvation or response to infection.\u201d<\/span><\/p>\n

Mutations in autophagy genes can cause disease, the assembly said, and disruptions in the process have been linked to Parkinson\u2019s disease, Type 2 diabetes and cancer.<\/span><\/p>\n

Biography<\/span><\/p>\n

Like many scientists, Dr. Ohsumi, who was born in 1945 in Fukuoka, Japan, and received a Ph.D. from the University of Tokyo in 1974, floundered at first trying to find his way. He started out in chemistry but decided it was too established a field with few opportunities.<\/span><\/p>\n

So he switched to molecular biology. But his Ph.D. thesis was unimpressive, and he could not find a job. His adviser suggested a postdoctoral position at Rockefeller University in New York, where he was to study in vitro fertilization in mice.<\/span><\/p>\n

\u201cI grew very frustrated,\u201d he told the Journal of Cell Biology. He switched to studying yeast.<\/span><\/p>\n

He became an associate professor and established his research lab in 1988.<\/span><\/p>\n

There, at age 43, he made the discoveries that the Nobel Assembly recognized on Monday. Dr. Ohsumi later moved to the National Institute for Basic Biology, in Okazaki, and since 2009, he has been a professor at the Tokyo Institute of Technology.<\/span><\/p>\n

When he received the Canada Gairdner International Award last year, which is given for outstanding discoveries or contributions to medical science, he described himself to The Globe and Mail newspaper as \u201cjust a basic researcher in yeast.\u201d<\/span><\/p>\n

He acknowledged, however, that the process was seen as fundamental to human cell survival. \u201cI believe its relevance to many diseases will be discovered in the near future,\u201d he told the newspaper.<\/span><\/p>\n

Why did he win?<\/span><\/p>\n

Cells need to degrade proteins in development and in their normal lifetimes as well as during diseases like cancer, infection and starvation. Biologists knew there was a sack in the cell that seemed like a garbage dump, but few had bothered to ask much more about it. Dr. Ohsumi discovered how cells control degradation of their own proteins, what genes are involved, and what happens when autophagy goes awry.<\/span><\/p>\n

Why is his work important?<\/span><\/p>\n

Disruptions in autophagy are thought to underlie many conditions, including cancer, infections, neurological diseases and aging. And since autophagy is a fundamental and crucial function in cells, it can be important to understand how it is controlled and what its consequences are.<\/span><\/p>\n

Reactions<\/span><\/p>\n

\u201cAll I can say is, it\u2019s such an honor,\u201d Dr. Ohsumi told reporters at the Tokyo Institute of Technology, according to the Japanese broadcaster NHK. \u201cI\u2019d like to tell young people that not all can be successful in science, but it\u2019s important to rise to the challenge.\u201d<\/span><\/p>\n

Who won last year\u2019s Nobel Prize in Physiology or Medicine?<\/span><\/p>\n

William C. Campbell, Satoshi Omura and Tu Youyou were recognized for their use of modern laboratory techniques to discover anti-parasitic drugs long hidden in herbs and soil.<\/span><\/p>\n

When the next prizes will be announced<\/span><\/p>\n

Five more will be awarded in the days to come:<\/span><\/p>\n

\u25a0 The Nobel Prize in Physics will be announced on Tuesday in Sweden. Read about last year\u2019s winners, Takaaki Kajita and Arthur B. McDonald.<\/span><\/p>\n

\u25a0 The Nobel Prize in Chemistry will be announced on Wednesday in Sweden. Read about last year\u2019s winners, Tomas Lindahl, Paul L. Modrich and Aziz Sancar.<\/span><\/p>\n

\u25a0 The Nobel Peace Prize will be announced on Friday in Norway. Read about last year\u2019s winners, the National Dialogue Quartet of Tunisia.<\/span><\/p>\n

\u25a0 The Nobel Memorial Prize in Economic Science will be announced on Monday, Oct. 10, in Sweden. Read about last year\u2019s winner, Angus Deaton.<\/span><\/p>\n

\u25a0 The Nobel Prize in Literature will be announced on Thursday, Oct. 13, in Sweden. Read about last year\u2019s winner, Svetlana Alexievich.<\/span><\/p>\n

Source<\/strong> : http:\/\/www.nytimes.com\/2016\/10\/04\/science\/yoshinori-ohsumi-nobel-prize-medicine.html<\/span><\/p>\n

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